Custom Peptides
Cayman Chemical SynthetIc -KavaIn 10mg
A kavalactone with diverse biological activities; a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors (EC50s = 25 and 59 µM in the presence and absence of 300 µM (+)-kavain); reduces growth of WPMY-1 prostate cancer cells (IC50= 5.2 UG/ml); reduces LPS-induced TNF-α production in primary murine macrophages; reduces hind paw swelling and TNF-α production in a mouse model of collagen-induced arthritis; reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg)
Cayman Chemical ChLRIdoN NdIsalIcylIden 10mg
An inducer of ferroptosis; induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells at 3 µM; inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3 and 5 µM), as well as daunorubicine- and vincristine-resistant NALM-6 cells at 0.04-0.125 µM
Cayman Chemical SCIADOPITYSIN 10MG
A biflavonoid with diverse biological activities; reduces Aβ42-induced cytotoxicity in PC12 cells (EC50 = 9.84 μM); decreases methylglyoxal-induced insulin secretion, production of ROS, cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells from 0.1-10 μM; inhibits P-gp (IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells; inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss
Cayman Chemical PIclIdenoson 10mg
An adenosine A3 receptor agonist (Ki = 1.7 nM); selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively); reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion at 100 UG/kg; reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and the number of lung metastases in a model of metastatic murine melanoma; reduces colonic inflammatory cell infiltration and damage in a mouse model of DSS-induced colitis and in in IL-10-/- mice at 1 and 3 mg/kg
Cayman Chemical 5 7-DIhydroxychromon 10mg
A flavone decomposition product; inhibits 6-OHDA-induced increases in apoptosis and the intracellular ROS at 0.4, 2, and 10 µM; increases the levels of HO-1, NQO1, and GCLc in SH-SY5Y cells at 0.08-10 µM
Active Motif MODified™ Histone Peptide Array
The MODified Histone Peptide Array is a valuable research tool that can be used to screen antibodies, enzymes and proteins for cross-reactivity or binding interactions with histones and their post-translational modifications. The MODified Histone Peptide Arrays screen 59 acetylation, methylation, phosphorylation, and citrullination modifications on the N-terminal tails of histones H2A, H2B, H3 and H4. Each peptide array contains 384 unique histone modification combinations in duplicate, including up to four separate modifications on the same 19mer peptide. This extensive coverage of histone modifications enables the study not only of individual sites, but also the effects of neighboring modifications on recognition and binding. The simple array protocol works like a Western blot; no special equipment needed.
Cayman Chemical CaptoprIl DIsulfIde 10mg
A metabolite and degradation product of captopril; a potential impurity in commercial preparations of captopril; inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID50 = 0.231 mg/kg, i.v.)
Cayman Chemical MIrodenafIlhydrochlorIde 10mg
A PDE5 inhibitor; increases penile ICP in rat models of STZ-induced diabetes and cavernosal nerve injury at 1 and 10 mg/kg, respectively; decreases bladder wall submucosal fibrosis and degeneration in a rat model of chronic bladder ischemia at 4 mg/kg per day; decreases bladder overactivity in a female rat model of partial bladder outlet obstruction
Cayman Chemical GInsenosIde Rc 10mg
A saponin; prevents UVB-induced increases in ROS levels in HaCaT keratinocytes by 34.3, 54.4, and 65.4% when used at concentrations of 5, 12, and 30 µM, respectively; reduces increases in LPS-induced expression of Tnf, Il1b, and Ifnb1 in RAW 264.7 cells at 40 UG/ml; reduces gastric ulcer and joint lesion indices in mouse models of HCl/ethanol-induced gastritis and collagen-induced arthritis, respectively, as well as reduced increased serum levels of AST induced by LPS/D-galactosamine in a mouse model of hepatitis, at 20 mg/kg; increases GABA-induced inward current in Xenopus oocytes expressing recombinant human α1β1ɣ2S subunit-containing GABAA receptors (EC50 = 53.2 µM)
Cayman Chemical EpInhydrotetracyclInhydro 10mg
A degradation product of tetracycline; active against Pseudomonas, Agrobacterium, Moraxella, Bacillus, and E. coli (MIC50s = 0.75-16 mg/L)
Cayman Chemical ButyrylCoenzyme AsodIM sa 10mg
A short-chain acyl CoA; an intermediate in the synthesis of butyrate
Cayman Chemical MI-2hydrochlorIde 10mg
Potently binds menin, blocks the menin-MLL fusion protein interaction (IC50 = 0.45 μM), and induces apoptosis in cells expressing MLL fusion proteins
Cayman Chemical 25I-NBMDhydrochlorIde 10mg
A derivative of the hallucinogen 2C-I with high affinity (Ki = 0.049–0.21 nM) and activity (EC50 = 8.2 nM) at the serotonin receptor 5-HT2A; intended for research and forensic applications
Cayman Chemical Myrislignan 10MG
A lignan with diverse biological activities; inhibits hypocotyl or root growth of cress (IC50s = 429 and 517 µM, respectively); inhibits production of NO, increases in iNOS and COX-2 levels, and release of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells at 50 UG/ml; inhibits proliferation of, and induces apoptosis in, A549 lung cancer cells; reduces tumor growth in an A549 lung cancer mouse xenograft model at 3, 5, and 8 mg/kg; decreases parasite burden in the liver, brain, and spleen in a mouse model of T. gondii infection at 100 mg/kg
