Custom Peptides
Cayman Chemical DIfelIkefalIntrIfluoROCTA 10mg
A κ-opioid receptor agonist; activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay); inhibits forskolin-induced cAMP production in R1.G1 cells (EC50 = 0.048 nM); selective for KOR over MOR (EC50 = >1 µM in a transactivation assay); reduces acetic acid-induced writhing, as well as GNTI-induced scratching behavior, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively)
Cayman Chemical Schzndrn 10mg
A lignan with diverse biological activities; induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells at 100 μM; prevents glutamate-induced cytotoxicity, inhibits production of NO and ROS, and preserves the mitochondrial membrane potential in isolated rat cortical cells at 10 and 100 μM; reduces cisplatin-induced apoptosis in HK-2 cells; reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats at 1 and 10 mg/kg; enhances oxotremorine-induced tremors in mice; reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy at 10 mg/kg
Cayman Chemical SynthetIc PrunIn 10mg
A flavonoid glycoside with diverse biological activities; inhibits NA activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 3 and 4.53 µM, respectively); scavenges DPPH radicals in a cell-free assay at 2 µM; inhibits the activity of PTP1B (IC50 = 5.5 µM for the human enzyme); increases insulin-induced glucose uptake in insulin-resistant HepG2 cells; inhibits proliferation of, and induces apoptosis in, HL-60 cells
Cayman Chemical MetIprnolol 10mg
A β-AR antagonist; binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM); inhibits isoproterenol-induced relaxation in guinea pig atrium and fenoterol-induced relaxation in rat uterus (pA2s = 8.3 and 8.4, respectively); inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates (100 μM); decreases α-chymotrypsin-induced increases in IOP in rabbits when administered topically to the eye at a dose of 0.3%; inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%
Cayman Chemical GnoderIc AcId C1 10mg
A triterpenoid; inhibits ACE (IC50 = 745 µM); inhibits HIV-1 protease (IC50 = 180 µM); reduces the proliferation of murine Lewis lung carcinoma cells but not murine Meth A sarcoma cells (EC50s = 17 and >20 UG/ml, respectively); inhibits LPS-induced NF-κB phosphorylation and production of TNF-α in RAW 264.7 cells and PBMCs isolated from patients with asthma at 20 UG/ml
Cayman Chemical SynthetIc TectrIdIn 10mg
A flavonoid glycoside and phytoestrogen with diverse biological activities; scavenges hydroxyl radicals in a cell-free assay (IC50 = 178 UG/ml); inhibits the formation of TBARS in egg yolk (IC50 = 86 UG/ml); activates thyroid hormone receptor- or estrogen receptor-mediated transcription in GH3 and MCF-7 cells, respectively, in reporter assays at 200 µM; inhibits thapsigargin-induced production of PGE2 in isolated rat peritoneal macrophages at 10 and 30 µM; inhibits trabecular bone loss in a mouse model of ovariectomy-induced osteoporosis at 60 mg/kg
Cayman Chemical SynthetIc PInosylvIn 10mg
A stilbene with diverse biological activities; activates SIRT1 and induces glucose uptake in isolated rat L6 skeletal muscle myotubes; reduces radial growth in a panel of 28 plant pathogenic fungi at 100 μg/ml; reduces expression of MMP-2, MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells; reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer at 10 mg/kg; decreases hind paw volume and MPO activity in a rat model of adjuvant-induced arthritis; exhibits plant antifeedant activity against L. americanus
Cayman Chemical CTOPtrIfluoroacetate salt 10mg
An antagonist of the μ-opioid receptor (IC50 = 2.8 nM); selective for μ-opioid receptors over δ-opioid receptors (IC50 = 13,500 nM) and somatostatin receptors (IC50 = 24,000 nM); inhibits the antinociceptive effect of morphine in the tail flick test in mice (ED50 = 0.018 nmol) and reverses morphine-induced increases in locomotor activity (ED50 = 0.02 nmol); induces withdrawal symptoms in a mouse model of chronic morphine dependence
Cayman Chemical SKF 82958hydrobromIde 10mg
A dopamine D1 receptor agonist (K0.5 = 4 nM in a radioligand binding assay); selective for dopamine D1 over D2 receptors (K0.5 = 73 nM); induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50 = 491 nM); prevents and reverses fentanyl-induced respiratory depression in cats at 3 mg/kg; increases locomotion and rearing in rats
Cayman Chemical Dynole 34-2 10mg
A dynamin inhibitor (IC50s = 6.9 and 14.2 µM for dynamin 1 and dynamin 2 GTPase activity, respectively); induces multinucleation, inhibits cytokinesis, and induces apoptosis in HeLa cells at 10 µM; inhibits proliferation of several cancer cell lines (GI50s = 5.8-15 µM)
Cayman Chemical GnoderIc AcId G 10mg
A triterpenoid with anticancer and anti-inflammatory activities; inhibits proliferation of Meth A sarcoma cells (IC50 = 6.8 UG/ml); inhibits the production of NO in LPS-induced BV-2 microglial cells (IC50 = 5.77 µM)
Cayman Chemical TAS 115methnsulfonate 10mg
A multi-kinase inhibitor; an inhibitor of PDGFRα and PDGFRβ (IC50s = 0.81 and 7.06 nM, respectively), c-FMS (IC50 = 15 nM), VEGFR2 and VEGFR1 (IC50s = 30 and 140 nM, respectively), Met (IC50 = 32 nM), and FGFR2 (IC50 = 340 nM); inhibits Axl, c-Kit, Src, and FLT1; inhibits VEGF-induced VEGFR2 phosphorylation in HUVECs and Met phosphorylation in Met-amplified MKN45 cells; inhibits VEGF-dependent growth of HUVECs (IC50 = 0.019 µM); inhibits growth of Met-amplified MKN45 cells (GI50 = 0.032 µM); reduces tumor growth in a MKN45 mouse xenograft model (ED50 = 8 mg/kg)
Cayman Chemical COG133trIfluoROCTAte salt 10mg
A peptide fragment of ApoE and an α7 nAChR antagonist (IC50 = 720 nM); suppresses TNF-α and NO release in BV-2 microglia from 10-50 µM; reduces LPS-induced increases in brain levels of TNF-α and IL-6 in mice; decreases hippocampal neuronal degeneration and the latency to find the platform in the Morris water maze in a mouse model of closed head injury induced by surgical midline impact at 203 and 406 UG/kg; delays disease onset and reduces disease severity in a mouse model of EAE at 1 mg/kg
Cayman Chemical 6-hydroxy Etodolac 10mg
A metabolite of etodolac; induces false-positive reactions in diazo diagnostic tests for bilirubin in urine